1), resulting from progressive autoimmune loss of melanocytes from the involved areas. Generalized vitiligo is characterized clinically by acquired patches of white skin and overlying hair, usually multifocal and often bilateral ( 7, 8) ( Fig. Perhaps the most recognizable autoimmune disease is generalized vitiligo, with descriptions of its visually striking clinical manifestations dating back several millennia ( 7). The most prevalent are the autoimmune thyroid diseases (AITD), principally Hashimoto's disease and Graves' disease ( 2– 4), characterized by infiltration of the thyroid by thyroid-reactive T and B cells and by the production of thyroid autoantibodies ( 5, 6). More than 80 autoimmune diseases are known, at least one for almost every organ in the body ( 1). A utoimmune diseases are a diverse group of chronic disorders in which the immune system attacks one's own cells and tissues.
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